The Solumer platform's unique characteristics are achieved by a proprietary "bottom up" process. Initial noncovalent interactions between pre-selected combinations of polymers and lipophlic drug occur in the liquid composition. A subsequent drying process ensures a strengthening of these interactions resulting in a self-assembled polymer-drug complex in powder form.
The Solumer™ technology platform possesses distinct features which clearly differentiate it from other competitive technologies:
An easily scaleable and simple 2-step process: liquid feed preparation followed by drying;
The resultant powder is well-defined and exhibits the unique analytical “fingerprints” of Solumer™ complexes:
o Solubilized drug homogeneously interwoven into a polymer construct
o Modified thermal behavior of the drug with depressed melting temperature and enthalpy of melting ;
o Spontaneous formation of colloidal dispersions upon contact with aqueous biological media;
o Enhanced dissolution rate / solubility of the drug
These characteristics permit circumvention of the current "best in the art" formulation approaches, allowing to significantly exploit the full market potential of poorly soluble drugs.