The Synergy of the Essential Solumer™ Parameters is responsible for its outstanding performance.
Particle engineering during the spray-drying process Solubest’s proprietary technology implements spray-drying of API and polymer blend to produce submicron particles of API dispersed in a polymeric matrix. To achieve the optimum dispersion and smallest particle size, consideration based on expertise is given to the composition of the feed solution and polymeric matrix.
Nano and Submicron particles of active compounds are embedded in the polymer matrix.
Upon contact with water or biological fluids, the Solumer™ powder is self-dispersed to form uniform nano-colloids with a mean particle size at a range of 0.5-5 µm. The colloidal particle is not entirely monolithic; it is built from subunits of 50-100 nm.
Depressed melting point and enthalpy
Formulated API demonstrates significant reduction in melting temperature and enthalpy in comparison with raw crystalline material. Such a high energy state requires less energy for dissolution!
Less ordered-crystalline lattice:
Formulated API possesses a high energy crystalline structure, stabilized by interaction with polymers. Such a disordered structure reduces the dissolution energy barrier, inherent in the typical rigid crystal of poorly soluble actives!
SolumerTM: porous micro-aggregates
During the spray-drying process of API and polymer proprietary blend porous micro-aggregates of polymers embed the API nano-particles. The optimum result is achieved due to expertise based choice of the polymeric matrix composition.
Flowability – easy handling and processing
Compressibility – allows multiple dosage forms
Stability – long shelf life
Bulk instant powder easily disperses in liquid
Improved dissolution and solubility
Formulated API exhibits significantly higher solubility in standard and bio-relevant media compared to raw API and commercial drugs. Similarity in the saturation solubility of Solubest products in Fed and Fasted State Simulating Intestinal Fluids (FaSSIF& FeSSIF) can be translated into the decrease or complete elimination of the drug food effect.
| SoluBest Ltd., Weizmann Science Park, POB 4053 18 Einstein Street, Ness Ziona 74140, Israel |
| Tel: +972-8-940-3023 | Fax: +972-8-930-2878 | info(AT)solubest.com |