Fenofibrate is a lipophilic drug mainly used to reduce cholesterol levels in patients. It reduces low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) levels and increases high-density lipoprotein (HDL) levels.
Several Fenofibrate compositions have been developed or proposed to improve the solubility and bioavailability of Fenofibrate and to reduce the food effect on blood levels of the active drug.
Solubest’s fenofibrate product (SoluFeno) is an oral dosage form This formulation was developed using SolumerTM proprietary technology, based on non-covalent complexation of poorly water-soluble pharmaceuticals with regulatory approved polymers
A comparison of the bioavailability of SoluFeno to reference product, Tricor 145.
Similarity was found in the saturation solubility of Solubest products in Fed and Fasted State Simulating Intestinal Fluids (FaSSIF& FeSSIF) compared to that of the commercial product, that is defined as food independent, which may imply food independence of the SoluFenofibrate. This feature is very important for patient compliance and drug potency.
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