Solubest has independently reached advanced stages of development of several formulations of generic compounds. One product, Resveratrol, is ready for manufacturing and distribution; another, Fenofibrate is at the clinical stage; and Testosteron Undeconoate and Albendazole are at the pre-clinical stage.
Solubest’s fenofibrate product (SoluFeno) is an oral dosage form. It is an immediate release tablet that has a 145 mg dose of the lipid regulating agent fenofibrate. This formulation was developed using SolumerTM proprietary technology, based on non-covalent self-assembly of poorly water-soluble fenofibrate with regulatory approved polymers. Preclinical and clinical trials that were conducted demonstrated promising results, and the product is ready for scale-up.
Albendazole is an orally administered broad-spectrum benzimidazole anthelmintic used against helminthes as well asin the treatment of hydatid cyst disease and neurocysticercosis. Ablendazole is a white to off-white powder, insoluble in water and poorly absorbed from the GI tract; however, it is quickly converted into its primary active metabolite, Albendazole sulfoxide.
SoluAlbendazole is and innovative product developed by Solubest Ltd with the goal of improving Albendazole's bioavailability. Pre-clinical trialswere conducted, and PK and efficacy data is available. Albendazole is ready for use for veterinary applications.
Resveratrol (RSV) is a naturally occurring polyphenol, found in grapes, red wine, berries, peanuts and many other plants. It has been shown to possess a multitude of health-promoting properties, including the management of age-related disorders, obesity, metabolic syndrome, type II diabetes mellitus, and so forth. RSV is practically insoluble in aqueous media; it demonstrates very low bioavailability and rapid, extensive metabolism, resulting in only trace amounts of unchanged resveratrol in the systemic circulation. Solubest developed a highly bioavailable formulation of Resveratrol (SoluRSV) utilizing Solumer™ proprietary technology. SoluRSV may be used either as a natureceutical supplement in capsules or as additive to custom formulations.
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